ExuR

• Description: repression of the hexuronate utilization operon (uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA)
  
  

Gene name	exuR
Synonyms	yjmH
Essential	no
Product	transcriptional repressor (LacI family)
Function	regulation of hexuronate utilization
Gene expression levels in SubtiExpress: exuR
MW, pI	37 kDa, 5.846
Gene length, protein length	999 bp, 333 aa
Immediate neighbours	exuT, uxaB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control, sporulation proteins

This gene is a member of the following regulons

CcpA regulon, ExuR regulon, SigE regulon

The ExuR regulon:

• uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA

The gene

Basic information

• Locus tag: BSU12370

Database entries

• BsubCyc: BSU12370

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: LacI family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: galacturonate acts as the molecular inducer PubMed

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU12370

• Structure:

• UniProt: Q9JMQ1

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed
  • yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed

• Expression browser: exuR PubMed

• Sigma factor: SigE PubMed
  • uxaC: SigA PubMed
  • yjmC: SigE PubMed

• Regulation:
  • repressed by glucose (CcpA) PubMed1 PubMed2
  • induced by galacturonate (ExuR) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed1 PubMed2
  • ExuR: reanscription repression in the absence of inducer PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 91 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 346 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: