DivIB

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  • Description: cell-division initiation protein (septum formation)

Gene name divIB
Synonyms dds, tms-12
Essential yes PubMed
Product cell-division protein
Function septum formation
Gene expression levels in SubtiExpress: divIB
Interactions involving this protein in SubtInteract: DivIB
Metabolic function and regulation of this protein in SubtiPathways:
divIB
MW, pI 30 kDa, 9.244
Gene length, protein length 789 bp, 263 aa
Immediate neighbours murB, ylxW
Sequences Protein DNA DNA_with_flanks
Genetic context
DivIB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
DivIB expression.png




























Categories containing this gene/protein

cell division, sporulation proteins, cell envelope stress proteins (controlled by SigM, V, W, X, Y), essential genes, membrane proteins

This gene is a member of the following regulons

SigE regulon, SigM regulon, SpoIIID regulon

The gene

Basic information

  • Locus tag: BSU15240

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ftsQ family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2ALJ (major extracytoplasmic domain, Geobacillus stearothermophilus)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional references: PubMed

Tatsuya Fukushima, Isako Furihata, Robyn Emmins, Richard A Daniel, James A Hoch, Hendrik Szurmant
A role for the essential YycG sensor histidine kinase in sensing cell division.
Mol Microbiol: 2011, 79(2);503-22
[PubMed:21219466] [WorldCat.org] [DOI] (I p)

Pamela Gamba, Jan-Willem Veening, Nigel J Saunders, Leendert W Hamoen, Richard A Daniel
Two-step assembly dynamics of the Bacillus subtilis divisome.
J Bacteriol: 2009, 191(13);4186-94
[PubMed:19429628] [WorldCat.org] [DOI] (I p)

Warawan Eiamphungporn, John D Helmann
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.
Mol Microbiol: 2008, 67(4);830-48
[PubMed:18179421] [WorldCat.org] [DOI] (P p)

L S Thompson, P L Beech, G Real, A O Henriques, E J Harry
Requirement for the cell division protein DivIB in polar cell division and engulfment during sporulation in Bacillus subtilis.
J Bacteriol: 2006, 188(21);7677-85
[PubMed:16936026] [WorldCat.org] [DOI] (P p)

Richard A Daniel, Marie-Françoise Noirot-Gros, Philippe Noirot, Jeff Errington
Multiple interactions between the transmembrane division proteins of Bacillus subtilis and the role of FtsL instability in divisome assembly.
J Bacteriol: 2006, 188(21);7396-404
[PubMed:16936019] [WorldCat.org] [DOI] (P p)

Gonçalo Real, Sabine Autret, Elizabeth J Harry, Jeffery Errington, Adriano O Henriques
Cell division protein DivIB influences the Spo0J/Soj system of chromosome segregation in Bacillus subtilis.
Mol Microbiol: 2005, 55(2);349-67
[PubMed:15659156] [WorldCat.org] [DOI] (P p)

V L Katis, R G Wake, E J Harry
Septal localization of the membrane-bound division proteins of Bacillus subtilis DivIB and DivIC is codependent only at high temperatures and requires FtsZ.
J Bacteriol: 2000, 182(12);3607-11
[PubMed:10852898] [WorldCat.org] [DOI] (P p)

R A Daniel, J Errington
Intrinsic instability of the essential cell division protein FtsL of Bacillus subtilis and a role for DivIB protein in FtsL turnover.
Mol Microbiol: 2000, 36(2);278-89
[PubMed:10792716] [WorldCat.org] [DOI] (P p)

V L Katis, R G Wake
Membrane-bound division proteins DivIB and DivIC of Bacillus subtilis function solely through their external domains in both vegetative and sporulation division.
J Bacteriol: 1999, 181(9);2710-8
[PubMed:10217758] [WorldCat.org] [DOI] (P p)

R A Daniel, E J Harry, V L Katis, R G Wake, J Errington
Characterization of the essential cell division gene ftsL(yIID) of Bacillus subtilis and its role in the assembly of the division apparatus.
Mol Microbiol: 1998, 29(2);593-604
[PubMed:9720875] [WorldCat.org] [DOI] (P p)

V L Katis, E J Harry, R G Wake
The Bacillus subtilis division protein DivIC is a highly abundant membrane-bound protein that localizes to the division site.
Mol Microbiol: 1997, 26(5);1047-55
[PubMed:9426141] [WorldCat.org] [DOI] (P p)

S L Rowland, V L Katis, S R Partridge, R G Wake
DivIB, FtsZ and cell division in Bacillus subtilis.
Mol Microbiol: 1997, 23(2);295-302
[PubMed:9044263] [WorldCat.org] [DOI] (P p)

E J Harry, S L Rowland, M S Malo, R G Wake
Expression of divIB of Bacillus subtilis during vegetative growth.
J Bacteriol: 1994, 176(4);1172-9
[PubMed:8106328] [WorldCat.org] [DOI] (P p)

G Theeragool, A Miyao, K Yamada, T Sato, Y Kobayashi
In vivo expression of the Bacillus subtilis spoVE gene.
J Bacteriol: 1993, 175(13);4071-80
[PubMed:8320223] [WorldCat.org] [DOI] (P p)

E J Harry, B J Stewart, R G Wake
Characterization of mutations in divIB of Bacillus subtilis and cellular localization of the DivIB protein.
Mol Microbiol: 1993, 7(4);611-21
[PubMed:8459777] [WorldCat.org] [DOI] (P p)

A O Henriques, H de Lencastre, P J Piggot
A Bacillus subtilis morphogene cluster that includes spoVE is homologous to the mra region of Escherichia coli.
Biochimie: 1992, 74(7-8);735-48
[PubMed:1391053] [WorldCat.org] [DOI] (P p)

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