FtsE

• Description: ABC transporter (ATP-binding protein) (FtsE-FtsX), required for CwlO activity (cell elongation) and for proper activation of Spo0A and initiation of sporulation
  
  

Gene name	ftsE
Synonyms
Essential	no
Product	ABC transporter (ATP-binding protein)
Function	control of cell wall synthesis
Gene expression levels in SubtiExpress: ftsE
Interactions involving this protein in SubtInteract: FtsE
MW, pI	25 kDa, 8.419
Gene length, protein length	684 bp, 228 aa
Immediate neighbours	ftsX, cccB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, cell wall synthesis, phosphorelay, membrane proteins

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

• Locus tag: BSU35260

Phenotypes of a mutant

• a ftsE mutation is synthetically lethal with a lytE mutation (due to a lack of autolysin activity) PubMed
• shorter, fatter cells, this can be rescued by addition of Mg(2+) PubMed
• reduced growth rate, especially at low Mg(2+) concentrations PubMed

Database entries

• BsubCyc: BSU35260

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • necessary for the autolysin activity of CwlO PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • FtsE-FtsX PubMed

• Localization: membrane associated (via FtsX) PubMed

Database entries

• BsubCyc: BSU35260

• Structure: 3TIF (ATP-binding protein from Methanococcus jannaschii, 40% identity) PubMed

• UniProt: O34814

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ftsE-ftsX (according to DBTBS)

• Expression browser: ftsE PubMed

• Sigma factor:

• Regulation:
  • repressed under conditions that trigger sporulation (Spo0A) PubMed

• Regulatory mechanism:
  • Spo0A: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: