YycI

• Description: negative effector of WalK, controls cell wall metabolism
  
  

Gene name	yycI
Synonyms
Essential	no
Product	negative effector of WalK
Function	control of cell wall metabolism
Gene expression levels in SubtiExpress: yycI
Interactions involving this protein in SubtInteract: YycI
MW, pI	32 kDa, 5.279
Gene length, protein length	840 bp, 280 aa
Immediate neighbours	walJ, yycH
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall/ other, transcription factors and their control, membrane proteins

The gene

Basic information

• Locus tag: BSU40380

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • forms dimers
  • YycH-YycI PubMed
  • WalK-YycI PubMed

• Localization: cell membrane (according to Swiss-Prot), spotty close to the membrane PubMed

Database entries

• Structure: 2O3O, PubMed

• UniProt: Q45612

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: walR-walK-yycH-yycI-walJ-htrC PubMed

• Expression browser: yycI PubMed

• Sigma factor:

• Regulation: expressed during vegetative growth, repressed during stationary phase PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Tatsuya Fukushima, Isako Furihata, Robyn Emmins, Richard A Daniel, James A Hoch, Hendrik Szurmant
A role for the essential YycG sensor histidine kinase in sensing cell division.
Mol Microbiol: 2011, 79(2);503-22
[PubMed:21219466] [WorldCat.org] [DOI] (I p)

Hendrik Szurmant, Lintao Bu, Charles L Brooks, James A Hoch
An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins.
Proc Natl Acad Sci U S A: 2008, 105(15);5891-6
[PubMed:18408157] [WorldCat.org] [DOI] (I p)

Patrick D McLaughlin, Benjamin G Bobay, Erin J Regel, Richele J Thompson, James A Hoch, John Cavanagh
Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition.
FEBS Lett: 2007, 581(7);1425-9
[PubMed:17350627] [WorldCat.org] [DOI] (P p)

Hendrik Szurmant, Michael A Mohan, P Michael Imus, James A Hoch
YycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis.
J Bacteriol: 2007, 189(8);3280-9
[PubMed:17307850] [WorldCat.org] [DOI] (P p)

Eugenio Santelli, Robert C Liddington, Michael A Mohan, James A Hoch, Hendrik Szurmant
The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins.
J Bacteriol: 2007, 189(8);3290-5
[PubMed:17307848] [WorldCat.org] [DOI] (P p)

C Fabret, J A Hoch
A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy.
J Bacteriol: 1998, 180(23);6375-83
[PubMed:9829949] [WorldCat.org] [DOI] (P p)