GerBB

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  • Description: nutrient receptor, germination response to the combination of glucose, fructose, and KCl

Gene name gerBB
Synonyms
Essential no
Product nutrient receptor
Function germination
Gene expression levels in SubtiExpress: gerBB
Interactions involving this protein in SubtInteract: GerBB
MW, pI 41 kDa, 9.889
Gene length, protein length 1104 bp, 368 aa
Immediate neighbours gerBA, gerBC
Sequences Protein DNA DNA_with_flanks
Genetic context
GerBB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GerBB expression.png















Categories containing this gene/protein

germination, membrane proteins

This gene is a member of the following regulons

SigG regulon

The gene

Basic information

  • Locus tag: BSU35810

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • amino acid, polyamine, organocation (APC) family of transporters, TC 2.A.3

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • expressed late during sporulation in the forespore (SigG) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Jing-qiao Zhang, Keren K Griffiths, Ann Cowan, Peter Setlow, Ji Yu
Expression level of Bacillus subtilis germinant receptors determines the average rate but not the heterogeneity of spore germination.
J Bacteriol: 2013, 195(8);1735-40
[PubMed:23396907] [WorldCat.org] [DOI] (I p)

Keren K Griffiths, Jingqiao Zhang, Ann E Cowan, Ji Yu, Peter Setlow
Germination proteins in the inner membrane of dormant Bacillus subtilis spores colocalize in a discrete cluster.
Mol Microbiol: 2011, 81(4);1061-77
[PubMed:21696470] [WorldCat.org] [DOI] (I p)

Swaroopa Atluri, Katerina Ragkousi, Donna E Cortezzo, Peter Setlow
Cooperativity between different nutrient receptors in germination of spores of Bacillus subtilis and reduction of this cooperativity by alterations in the GerB receptor.
J Bacteriol: 2006, 188(1);28-36
[PubMed:16352818] [WorldCat.org] [DOI] (P p)

Takao Igarashi, Peter Setlow
Interaction between individual protein components of the GerA and GerB nutrient receptors that trigger germination of Bacillus subtilis spores.
J Bacteriol: 2005, 187(7);2513-8
[PubMed:15774895] [WorldCat.org] [DOI] (P p)

Rosa-Martha Cabrera-Martinez, Federico Tovar-Rojo, Venkata Ramana Vepachedu, Peter Setlow
Effects of overexpression of nutrient receptors on germination of spores of Bacillus subtilis.
J Bacteriol: 2003, 185(8);2457-64
[PubMed:12670969] [WorldCat.org] [DOI] (P p)

M Paidhungat, P Setlow
Isolation and characterization of mutations in Bacillus subtilis that allow spore germination in the novel germinant D-alanine.
J Bacteriol: 1999, 181(11);3341-50
[PubMed:10348844] [WorldCat.org] [DOI] (P p)

B M Corfe, A Moir, D Popham, P Setlow
Analysis of the expression and regulation of the gerB spore germination operon of Bacillus subtilis 168.
Microbiology (Reading): 1994, 140 ( Pt 11);3079-83
[PubMed:7812448] [WorldCat.org] [DOI] (P p)

B M Corfe, R L Sammons, D A Smith, C Mauël
The gerB region of the Bacillus subtilis 168 chromosome encodes a homologue of the gerA spore germination operon.
Microbiology (Reading): 1994, 140 ( Pt 3);471-8
[PubMed:8012571] [WorldCat.org] [DOI] (P p)