YqeL

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  • Description: ribosomal silencing factor

Gene name yqeL
Synonyms
Essential no
Product ribosomal silencing factor
Function translation
Gene expression levels in SubtiExpress: yqeL
Interactions involving this protein in SubtInteract: YqeL
MW, pI 13 kDa, 4.367
Gene length, protein length 354 bp, 118 aa
Immediate neighbours yqeM, yqeK
Sequences Protein DNA DNA_with_flanks
Genetic context
YqeL context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YqeL expression.png















Categories containing this gene/protein

translation

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU25620

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • silences translation by binding to the L14 protein of the large ribosomal subunit and, as a consequence, impairs subunit joining PubMed
  • Protein family: Iojap family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

  • the protein is enriched in 45S assembly intermediates that accumulate upon depletion of RbgA PubMed

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ningning Li, Yuling Chen, Qiang Guo, Yixiao Zhang, Yi Yuan, Chengying Ma, Haiteng Deng, Jianlin Lei, Ning Gao
Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit.
Nucleic Acids Res: 2013, 41(14);7073-83
[PubMed:23700310] [WorldCat.org] [DOI] (I p)

Roman Häuser, Markus Pech, Jaroslaw Kijek, Hiroshi Yamamoto, Björn Titz, Florian Naeve, Andrey Tovchigrechko, Kaori Yamamoto, Witold Szaflarski, Nono Takeuchi, Thorsten Stellberger, Markus E Diefenbacher, Knud H Nierhaus, Peter Uetz
RsfA (YbeB) proteins are conserved ribosomal silencing factors.
PLoS Genet: 2012, 8(7);e1002815
[PubMed:22829778] [WorldCat.org] [DOI] (I p)