DgrA

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  • Description: c-di-GMP receptor protein, inhibits motility at high c-di-GMP concentrations

Gene name dgrA
Synonyms ypfA, jofA
Essential no
Product c-di-GMP receptor protein
Function control of MotA activity
Gene expression levels in SubtiExpress: DgrA
Interactions involving this protein in SubtInteract: DgrA
MW, pI 24 kDa, 7.878
Gene length, protein length 651 bp, 217 aa
Immediate neighbours ypfB, ypeB
Sequences Protein DNA DNA_with_flanks
Genetic context
YpfA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YpfA expression.png















Categories containing this gene/protein

motility and chemotaxis

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU22910

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
    • K(D) for c-di-GMP: 1.1 nM PubMed
  • Domains:
    • contains a C-terminal PilZ domain PubMed
  • Modification:
  • Effectors of protein activity:
    • binding of c-di-GMP stimulates the inhibitory interaction with MotA PubMed

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Xiaohui Gao, Sampriti Mukherjee, Paige M Matthews, Loubna A Hammad, Daniel B Kearns, Charles E Dann
Functional characterization of core components of the Bacillus subtilis cyclic-di-GMP signaling pathway.
J Bacteriol: 2013, 195(21);4782-92
[PubMed:23893111] [WorldCat.org] [DOI] (I p)

Yun Chen, Yunrong Chai, Jian-hua Guo, Richard Losick
Evidence for cyclic Di-GMP-mediated signaling in Bacillus subtilis.
J Bacteriol: 2012, 194(18);5080-90
[PubMed:22821967] [WorldCat.org] [DOI] (I p)