SipT

• Description: signal peptidase I
  
  

Gene name	sipT
Synonyms
Essential	no
Product	signal peptidase I
Function	protein secretion
Gene expression levels in SubtiExpress: sipT
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	21 kDa, 9.851
Gene length, protein length	579 bp, 193 aa
Immediate neighbours	fruA, ykoA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein secretion, membrane proteins

This gene is a member of the following regulons

DegU regulon

The gene

Basic information

• Locus tag: BSU14410

Database entries

• BsubCyc: BSU14410

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)

• Protein family: peptidase S26 family (according to Swiss-Prot)

• Paralogous protein(s): SipS, SipU, SipV

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU14410

• Structure:

• UniProt: P71013

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sipT PubMed

• Expression browser: sipT PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • DegU: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Jan Maarten van Dijl, Groningen, Netherlands

References

Reviews

Ross E Dalbey, Peng Wang, Jan Maarten van Dijl
Membrane proteases in the bacterial protein secretion and quality control pathway.
Microbiol Mol Biol Rev: 2012, 76(2);311-30
[PubMed:22688815] [WorldCat.org] [DOI] (I p)