PadC

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  • Description: phenolic acid decarboxylase

Gene name padC
Synonyms pad, yveH
Essential no
Product phenolic acid decarboxylase
Function resistance to salicylic acid
Gene expression levels in SubtiExpress: padC
MW, pI 18 kDa, 4.871
Gene length, protein length 483 bp, 161 aa
Immediate neighbours pnbA, yveG
Sequences Protein DNA DNA_with_flanks
Genetic context
PadC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PadC expression.png
























Categories containing this gene/protein

resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)

This gene is a member of the following regulons

PadR regulon

The gene

Basic information

  • Locus tag: BSU34400

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: padC family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: induced by phenolic acid (PadR) PubMed
  • Regulatory mechanism: PadR: transcription repression PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Thi Kim Chi Nguyen, Ngoc Phuong Tran, Jean-François Cavin
Genetic and biochemical analysis of PadR-padC promoter interactions during the phenolic acid stress response in Bacillus subtilis 168.
J Bacteriol: 2011, 193(16);4180-91
[PubMed:21685295] [WorldCat.org] [DOI] (I p)

Ngoc Phuong Tran, Jerôme Gury, Véronique Dartois, Thi Kim Chi Nguyen, Hélène Seraut, Lise Barthelmebs, Patrick Gervais, Jean-François Cavin
Phenolic acid-mediated regulation of the padC gene, encoding the phenolic acid decarboxylase of Bacillus subtilis.
J Bacteriol: 2008, 190(9);3213-24
[PubMed:18326577] [WorldCat.org] [DOI] (I p)

Nguyen Van Duy, Ulrike Mäder, Ngoc Phuong Tran, Jean-François Cavin, Le Thi Tam, Dirk Albrecht, Michael Hecker, Haike Antelmann
The proteome and transcriptome analysis of Bacillus subtilis in response to salicylic acid.
Proteomics: 2007, 7(5);698-710
[PubMed:17295427] [WorldCat.org] [DOI] (P p)

J F Cavin, V Dartois, C Diviès
Gene cloning, transcriptional analysis, purification, and characterization of phenolic acid decarboxylase from Bacillus subtilis.
Appl Environ Microbiol: 1998, 64(4);1466-71
[PubMed:9546183] [WorldCat.org] [DOI] (P p)