SftA

• Description: DNA translocase
  
  

Gene name	sftA
Synonyms	ytpS, cdtA
Essential	no
Product	DNA translocase
Function	resolution of chromosome dimers
Gene expression levels in SubtiExpress: sftA
MW, pI	107 kDa, 5.052
Gene length, protein length	2856 bp, 952 aa
Immediate neighbours	murC, ytpR
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA condensation/ segregation

The gene

Basic information

• Locus tag: BSU29805

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • aids in moving DNA away from the closing septum, binds DNA, DNA-dependent ATPase activity PubMed
  • the two DNA translocases SftA and SpoIIIE synergistically affect chromosome dimer resolution presumably by positioning the dif sites in close proximity, before or after completion of cell division, respectively PubMed

• Protein family:

• Paralogous protein(s): SpoIIIE

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • forms a hexamer PubMed

• Localization:
  • Cytoplasm (Homogeneous) PubMed
  • co-localizes with FtsZ at nascent division sites PubMed

Database entries

• Structure:

• UniProt: C0SP86

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: sftA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A984 ( sftA::spec), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Rodrigo Reyes-Lamothe, Emilien Nicolas, David J Sherratt
Chromosome replication and segregation in bacteria.
Annu Rev Genet: 2012, 46;121-43
[PubMed:22934648] [WorldCat.org] [DOI] (I p)

Christine Kaimer, Peter L Graumann
Players between the worlds: multifunctional DNA translocases.
Curr Opin Microbiol: 2011, 14(6);719-25
[PubMed:22047950] [WorldCat.org] [DOI] (I p)