RefZ

• Description: regulator of FtsZ (TetR family), facilitates switch from medial to polar FtsZ ring placement during sporulation
  
  

Gene name	refZ
Synonyms	yttP
Essential	no
Product	regulator of FtsZ
Function	relocalization of the FtsZ ring
Interactions involving this protein in SubtInteract: RefZ
MW, pI	24 kDa, 6.706
Gene length, protein length	621 bp, 207 aa
Immediate neighbours	hisJ, ytsP
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell division, sporulation/ other

This gene is a member of the following regulons

CcpA regulon, PhoP regulon, Spo0A regulon

The gene

Basic information

• Locus tag: BSU29630

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: facilitates switch from medial to polar FtsZ ring placement during sporulation PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:
  • TetR-like DNA-binding helix-turn-helix domain at the N-terminus PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RefZ-FtsZ PubMed

• Localization:
  • polar foci PubMed

Database entries

• Structure:

• UniProt: O34970

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: refZ PubMed

• Expression browser: refZ PubMed

• Sigma factor:

• Regulation:
  • repressed by glucose (3.1-fold) (CcpA) PubMed
  • induced early during sporulation (Spo0A) PubMed
  • expressed under conditions of phosphate limitation (PhoP) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed
  • Spo0A: transcription activation PubMed
  • PhoP: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Leslie Cuthbertson, Justin R Nodwell
The TetR family of regulators.
Microbiol Mol Biol Rev: 2013, 77(3);440-75
[PubMed:24006471] [WorldCat.org] [DOI] (I p)