UvrX

• Description: UV-damage repair protein
  
  

Gene name	uvrX
Synonyms	yolE
Essential	no
Product	UV-damage repair protein
Function	DNA repair after UV damage
Gene expression levels in SubtiExpress: uvrX
MW, pI	46 kDa, 9.631
Gene length, protein length	1248 bp, 416 aa
Immediate neighbours	sunI, yolD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination, SP-beta prophage

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

• Locus tag: BSU21500

Database entries

• BsubCyc: BSU21500

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: DNA polymerase type-Y family

• Paralogous protein(s): PolY1, UvrX, YozK-YobH

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU21500

• Structure:

• UniProt: O31990

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yolD-uvrX PubMed

• Expression browser: uvrX PubMed

• Sigma factor:

• Regulation:
  • induced by DNA damage (LexA) PubMed

• Regulatory mechanism:
  • LexA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Nora Au, Elke Kuester-Schoeck, Veena Mandava, Laura E Bothwell, Susan P Canny, Karen Chachu, Sierra A Colavito, Shakierah N Fuller, Eli S Groban, Laura A Hensley, Theresa C O'Brien, Amish Shah, Jessica T Tierney, Louise L Tomm, Thomas M O'Gara, Alexi I Goranov, Alan D Grossman, Charles M Lovett
Genetic composition of the Bacillus subtilis SOS system.
J Bacteriol: 2005, 187(22);7655-66
[PubMed:16267290] [WorldCat.org] [DOI] (P p)