YonT

• Description: toxin
  
  

Gene name	yonT
Synonyms
Essential	no
Product	toxin
Function	unknown
Gene expression levels in SubtiExpress: yonT
MW, pI	6 kDa, 12.857
Gene length, protein length	174 bp, 58 aa
Immediate neighbours	as-yonT, yonS
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

toxins, antitoxins and immunity against toxins, SP-beta prophage

This gene is a member of the following regulons

as-yonT regulon

The gene

Basic information

• Locus tag: BSU21000

Database entries

• BsubCyc: BSU21000

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: panD family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU21000

• Structure:

• UniProt: O31941

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: yonT PubMed

• Sigma factor:

• Regulation:
  • the yonT mRNA-as-yonT RNA duplex is degraded by RNase III PubMed

• Regulatory mechanism:

• Additional information:
  • next to txpA, the yonT mRNA has the strongest Shine-Dalgarno region in B. subtilis PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Fabian M Commichau, Jörg Stülke
A mystery unraveled: essentiality of RNase III in Bacillus subtilis is caused by resident prophages.
PLoS Genet: 2012, 8(12);e1003199
[PubMed:23300472] [WorldCat.org] [DOI] (I p)

Original publications

Durand S, Gilet L, Condon C  
The essential function of B. subtilis RNase III is to silence foreign toxin genes. 
PLoS Genet. 2012 8(12): e1003181.
PubMed:23300471

Elizabeth M Fozo, Kira S Makarova, Svetlana A Shabalina, Natalya Yutin, Eugene V Koonin, Gisela Storz
Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families.
Nucleic Acids Res: 2010, 38(11);3743-59
[PubMed:20156992] [WorldCat.org] [DOI] (I p)

Roula Daou-Chabo, Nathalie Mathy, Lionel Bénard, Ciarán Condon
Ribosomes initiating translation of the hbs mRNA protect it from 5'-to-3' exoribonucleolytic degradation by RNase J1.
Mol Microbiol: 2009, 71(6);1538-50
[PubMed:19210617] [WorldCat.org] [DOI] (I p)