GltR

• Description: transcriptional regulator (LysR family)
  
  

Gene name	gltR
Synonyms	yrdL
Essential	no
Product	transcriptional regulator (LysR family)
Function	unknown
Gene expression levels in SubtiExpress: gltR
MW, pI	32 kDa, 6.653
Gene length, protein length	888 bp, 296 aa
Immediate neighbours	yrdN, yrdK
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control

This gene is a member of the following regulons

GltR regulon

The GltR regulon:

• gltR

The gene

Basic information

• Locus tag: BSU26670

Phenotypes of a mutant

The function of this protein is unknown. However, certain mutant forms are able to activate expression of the gltA-gltB operon (and thus to replace the cognate activator protein GltC)

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: LysR family of transcription factors

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P94501

• KEGG entry: [3]

• E.C. number:

Additional information

The function of this protein is unknown. However, certain mutant forms are able to activate expression of the gltA-gltB operon (and thus to replace the cognate activator protein GltC)

Expression and regulation

• Operon: gltR (according to DBTBS)

• Expression browser: gltR PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • GltR: negative autoregulation PubMed

• Additional information:

Biological materials

• Mutant: GP345 (erm), available in the Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Linc Sonenshein, Tufts University, Boston, MA, USA Homepage

References

B R Belitsky, A L Sonenshein
Altered transcription activation specificity of a mutant form of Bacillus subtilis GltR, a LysR family member.
J Bacteriol: 1997, 179(4);1035-43
[PubMed:9023181] [WorldCat.org] [DOI] (P p)