AroC

• Description: 3-dehydroquinate dehydratase
  
  

Gene name	aroC
Synonyms
Essential	no
Product	3-dehydroquinate dehydratase
Function	biosynthesis of aromatic amino acids
Gene expression levels in SubtiExpress: aroC
Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp
MW, pI	27 kDa, 4.898
Gene length, protein length	765 bp, 255 aa
Immediate neighbours	serA, rsiX
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

The gene

Basic information

• Locus tag: BSU23080

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 3-dehydroquinate = 3-dehydroshikimate + H₂O (according to Swiss-Prot)

• Protein family: type-I 3-dehydroquinase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1GQN (from Salmonella typhi, 55% identity, 70% similarity) PubMed

• UniProt: P35146

• KEGG entry: [3]

• E.C. number: 4.2.1.10

Expression and regulation

• Operon: aroC PubMed

• Expression browser: aroC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

V Azevedo, A Sorokin, S D Ehrlich, P Serror
The transcriptional organization of the Bacillus subtilis 168 chromosome region between the spoVAF and serA genetic loci.
Mol Microbiol: 1993, 10(2);397-405
[PubMed:7934830] [WorldCat.org] [DOI] (P p)

R J Warburg, I Mahler, D J Tipper, H O Halvorson
Cloning the Bacillus subtilis 168 aroC gene encoding dehydroquinase.
Gene: 1984, 32(1-2);57-66
[PubMed:6442253] [WorldCat.org] [DOI] (P p)