Ndk

From SubtiWiki
Revision as of 13:45, 16 May 2013 by 134.76.70.252 (talk)
Jump to: navigation, search
  • Description: nucleoside diphosphate kinase

Gene name ndk
Synonyms
Essential no
Product nucleoside diphosphate kinase
Function maintainance of an equilibrium between the
concentrations of different nucleoside triphosphates
Gene expression levels in SubtiExpress: ndk
Metabolic function and regulation of this protein in SubtiPathways:
Pyrimidines, Purine salvage
MW, pI 16 kDa, 5.568
Gene length, protein length 447 bp, 149 aa
Immediate neighbours cheR, hepT
Sequences Protein DNA DNA_with_flanks
Genetic context
Ndk context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Ndk expression.png




























Categories containing this gene/protein

nucleotide metabolism/ other, phosphoproteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU22730

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate (according to Swiss-Prot)
  • Protein family: phosphate acetyltransferase and butyryltransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation on Thr-92 AND Ser-123 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1WKJ (from Thermus thermophilus, 59% identity, 82% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References