PgsA

• Description: phosphatidylglycerophosphate synthase
  
  

Gene name	pgsA
Synonyms	ymfN
Essential	yes PubMed
Product	phosphatidylglycerophosphate synthase
Function	biosynthesis of phospholipids
Gene expression levels in SubtiExpress: pgsA
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	21 kDa, 5.163
Gene length, protein length	579 bp, 193 aa
Immediate neighbours	rodZ, cinA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of lipids, essential genes, membrane proteins

The gene

Basic information

• Locus tag: BSU16920

Phenotypes of a mutant

• some point mutations resulting in reduced PgsA activity lead to daptomycin resistance PubMed

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (according to Swiss-Prot)

• Protein family: CDP-alcohol phosphatidyltransferase class-I family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane at the septum PubMed

Database entries

• Structure:

• UniProt: P46322

• KEGG entry: [2]

• E.C. number: 2.7.8.5

Expression and regulation

• Operon:

• Expression browser: pgsA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A815 ( pgsA::erm), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: