ProB

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  • Description: glutamate 5-kinase

Gene name proB
Synonyms
Essential no
Product glutamate 5-kinase
Function biosynthesis of proline
Gene expression levels in SubtiExpress: proB
Metabolic function and regulation of this protein in SubtiPathways:
Pro, Stress
MW, pI 39 kDa, 6.01
Gene length, protein length 1095 bp, 365 aa
Immediate neighbours ykkE, proA
Sequences Protein DNA DNA_with_flanks
Genetic context
ProB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ProB expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

T-box

The gene

Basic information

  • Locus tag: BSU13120

Phenotypes of a mutant

  • auxotrophic for proline PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + L-glutamate = ADP + L-glutamate 5-phosphate (according to Swiss-Prot)
  • Protein family: PUA domain (according to Swiss-Prot)
  • Paralogous protein(s): ProJ

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: the enzymatic activity is feedback-inhibited by proline {PubMed|16958849}}

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed