DegA

• Description: transcriptional activator involved in the degradation of glutamine phosphoribosylpyrophosphate amidotransferase
  
  

Gene name	degA
Synonyms
Essential	no
Product	transcriptional activator (LacI family)
Function	unknown
Gene expression levels in SubtiExpress: degA
MW, pI	36 kDa, 5.784
Gene length, protein length	1011 bp, 337 aa
Immediate neighbours	yisR, iolX
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control

The gene

Basic information

• Locus tag: BSU10840

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P37947

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: degA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information: the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

G Hambraeus, C von Wachenfeldt, L Hederstedt
Genome-wide survey of mRNA half-lives in Bacillus subtilis identifies extremely stable mRNAs.
Mol Genet Genomics: 2003, 269(5);706-14
[PubMed:12884008] [WorldCat.org] [DOI] (P p)

L B Bussey, R L Switzer
The degA gene product accelerates degradation of Bacillus subtilis phosphoribosylpyrophosphate amidotransferase in Escherichia coli.
J Bacteriol: 1993, 175(19);6348-53
[PubMed:8407808] [WorldCat.org] [DOI] (P p)