MntH

• Description: manganese transporter (proton symport)
  
  

Gene name	mntH
Synonyms	ydaR
Essential	no
Product	manganese transporter (proton symport))
Function	manganese uptake
Gene expression levels in SubtiExpress: mntH
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	45 kDa, 9.889
Gene length, protein length	1275 bp, 425 aa
Immediate neighbours	ydzK, ydaS
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), membrane proteins

This gene is a member of the following regulons

MntR regulon

The gene

Basic information

• Locus tag: BSU04360

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: NRAMP family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P96593

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mntH PubMed

• Expression browser: mntH PubMed

• Sigma factor:

• Regulation: repressed by Mn(2+) (MntR) PubMed
  • repressed at high Mn(II) concentrations (MntR) PubMed

• Regulatory mechanism: MntR: transcription repression PubMed
  • MntR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

References

Emmanuel Guedon, Charles M Moore, Qiang Que, Tao Wang, Rick W Ye, John D Helmann
The global transcriptional response of Bacillus subtilis to manganese involves the MntR, Fur, TnrA and sigmaB regulons.
Mol Microbiol: 2003, 49(6);1477-91
[PubMed:12950915] [WorldCat.org] [DOI] (P p)

Q Que, J D Helmann
Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins.
Mol Microbiol: 2000, 35(6);1454-68
[PubMed:10760146] [WorldCat.org] [DOI] (P p)