LacR

• Description: transcriptional repressor of the galactan utilization operon
  
  

Gene name	lacR
Synonyms	yvfJ
Essential	no
Product	transcriptional repressor (LacI family)
Function	regulation of galactan utilization
Gene expression levels in SubtiExpress: lacR
MW, pI	37 kDa, 5.396
Gene length, protein length	990 bp, 330 aa
Immediate neighbours	cycB, lutR
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

The LacR regulon:

• cycB-ganP-ganQ-ganA-ganB

The gene

Basic information

• Locus tag: BSU34170

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: LacI family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O07008

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: lacR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant: GP815 (spc) available in the Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

R A Daniel, J Haiech, F Denizot, J Errington
Isolation and characterization of the lacA gene encoding beta-galactosidase in Bacillus subtilis and a regulator gene, lacR.
J Bacteriol: 1997, 179(17);5636-8
[PubMed:9287030] [WorldCat.org] [DOI] (P p)

J Errington, C H Vogt
Isolation and characterization of mutations in the gene encoding an endogenous Bacillus subtilis beta-galactosidase and its regulator.
J Bacteriol: 1990, 172(1);488-90
[PubMed:2104611] [WorldCat.org] [DOI] (P p)