BceS

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  • Description: two-component sensor kinase, regulation of bceA-bceB in response to bacitracin, plectasin, mersacidin and actagardine

Gene name bceS
Synonyms ytsB
Essential no
Product two-component sensor kinase (OmpR family)
Function resistance against toxic peptides
Gene expression levels in SubtiExpress: bceS
Interactions involving this protein in SubtInteract: BceS
MW, pI 38 kDa, 5.939
Gene length, protein length 1002 bp, 334 aa
Immediate neighbours bceA, bceR
Sequences Protein DNA DNA_with_flanks
Genetic context
YtsB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
BceS expression.png















Categories containing this gene/protein

protein modification, transcription factors and their control, resistance against toxins/ antibiotics, membrane proteins, phosphoproteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU30390

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of BceR
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain
  • Modification: autophosphorylation on a His residue
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Stéphanie Coumes-Florens, Céline Brochier-Armanet, Annick Guiseppi, François Denizot, Maryline Foglino
A new highly conserved antibiotic sensing/resistance pathway in firmicutes involves an ABC transporter interplaying with a signal transduction system.
PLoS One: 2011, 6(1);e15951
[PubMed:21283517] [WorldCat.org] [DOI] (I e)

Jing Ouyang, Xiao-Lin Tian, Jennifer Versey, Alexander Wishart, Yung-Hua Li
The BceABRS four-component system regulates the bacitracin-induced cell envelope stress response in Streptococcus mutans.
Antimicrob Agents Chemother: 2010, 54(9);3895-906
[PubMed:20606066] [WorldCat.org] [DOI] (I p)

Eva Rietkötter, Diana Hoyer, Thorsten Mascher
Bacitracin sensing in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);768-85
[PubMed:18394148] [WorldCat.org] [DOI] (I p)

Remi Bernard, Annick Guiseppi, Marc Chippaux, Maryline Foglino, François Denizot
Resistance to bacitracin in Bacillus subtilis: unexpected requirement of the BceAB ABC transporter in the control of expression of its own structural genes.
J Bacteriol: 2007, 189(23);8636-42
[PubMed:17905982] [WorldCat.org] [DOI] (I p)

Thorsten Mascher, Neil G Margulis, Tao Wang, Rick W Ye, John D Helmann
Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon.
Mol Microbiol: 2003, 50(5);1591-604
[PubMed:14651641] [WorldCat.org] [DOI] (P p)

Reiko Ohki, Giyanto, Kozue Tateno, Waka Masuyama, Shigeki Moriya, Kazuo Kobayashi, Naotake Ogasawara
The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
Mol Microbiol: 2003, 49(4);1135-44
[PubMed:12890034] [WorldCat.org] [DOI] (P p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672] [WorldCat.org] [DOI] (P p)