RapE

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Gene name rapE
Synonyms yqcH
Essential no
Product response regulator aspartate phosphatase
Function control of sporulation initiation
Gene expression levels in SubtiExpress: rapE
Interactions involving this protein in SubtInteract: RapE
Function and regulation of this protein in SubtiPathways:
Phosphorelay
MW, pI 44 kDa, 7.313
Gene length, protein length 1125 bp, 375 aa
Immediate neighbours yqcI, phrE
Sequences Protein DNA DNA_with_flanks
Genetic context
RapE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RapE expression.png















Categories containing this gene/protein

protein modification, transcription factors and their control, phosphorelay, quorum sensing, Skin element

This gene is a member of the following regulons

CodY regulon, ComA regulon

The gene

Basic information

  • Locus tag: BSU25830

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: RAP family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
    • ComA: transcription activation PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Boris R Belitsky, Abraham L Sonenshein
Genome-wide identification of Bacillus subtilis CodY-binding sites at single-nucleotide resolution.
Proc Natl Acad Sci U S A: 2013, 110(17);7026-31
[PubMed:23569278] [WorldCat.org] [DOI] (I p)

Virginie Molle, Yoshiko Nakaura, Robert P Shivers, Hirotake Yamaguchi, Richard Losick, Yasutaro Fujita, Abraham L Sonenshein
Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis.
J Bacteriol: 2003, 185(6);1911-22
[PubMed:12618455] [WorldCat.org] [DOI] (P p)

R S McQuade, N Comella, A D Grossman
Control of a family of phosphatase regulatory genes (phr) by the alternate sigma factor sigma-H of Bacillus subtilis.
J Bacteriol: 2001, 183(16);4905-9
[PubMed:11466295] [WorldCat.org] [DOI] (P p)

M Jiang, R Grau, M Perego
Differential processing of propeptide inhibitors of Rap phosphatases in Bacillus subtilis.
J Bacteriol: 2000, 182(2);303-10
[PubMed:10629174] [WorldCat.org] [DOI] (P p)