KduD

• Description: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
  
  

Gene name	kduD
Synonyms
Essential	no
Product
Function	utilization of galacturonic acid
Gene expression levels in SubtiExpress: kduD
MW, pI	27 kDa, 6.498
Gene length, protein length	762 bp, 254 aa
Immediate neighbours	kduI, ypvA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

CcpA regulon, KdgR regulon

The gene

Basic information

• Locus tag: BSU22140

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2-deoxy-D-gluconate + NAD⁺ = 3-dehydro-2-deoxy-D-gluconate + NADH (according to Swiss-Prot)

• Protein family: phosphopentomutase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P50842

• KEGG entry: [2]

• E.C. number: 1.1.1.125

Expression and regulation

• Operon: kduI-kduD PubMed

• Expression browser: kduD PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by galacturonate (KdgR) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • KdgR: transcription repression PubMed
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jer-Sheng Lin, Gwo-Chyuan Shaw
Regulation of the kduID operon of Bacillus subtilis by the KdgR repressor and the ccpA gene: identification of two KdgR-binding sites within the kdgR-kduI intergenic region.
Microbiology (Reading): 2007, 153(Pt 3);701-710
[PubMed:17322190] [WorldCat.org] [DOI] (P p)