YabM

• Description: may function in a previously observed alternate pathway for peptidoglycan strand synthesis
  
  

Gene name	yabM
Synonyms
Essential	no
Product	unknown
Function	alternate pathway for peptidoglycan strand synthesis
Gene expression levels in SubtiExpress: yabM
MW, pI	57 kDa, 9.623
Gene length, protein length	1596 bp, 532 aa
Immediate neighbours	spoVT, yabN
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, membrane proteins

The gene

Basic information

• Locus tag: BSU00570

Phenotypes of a mutant

Mutants lacking YabM exhibit sensitivity to moenomycin, an antibiotic that blocks peptidoglycan polymerization by class A penicillin-binding proteins. PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: may function in a previously observed alternate pathway for peptidoglycan strand synthesis PubMed

• Protein family: polysaccharide synthase family (according to Swiss-Prot)

• Paralogous protein(s): SpoVB, YkvU, YtgP

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P37555

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yabM-yabN-yabO-yabP-yabQ-divIC-yabR PubMed

• Expression browser: yabM PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Allison Fay, Jonathan Dworkin
Bacillus subtilis homologs of MviN (MurJ), the putative Escherichia coli lipid II flippase, are not essential for growth.
J Bacteriol: 2009, 191(19);6020-8
[PubMed:19666716] [WorldCat.org] [DOI] (I p)

Pradeep Vasudevan, Jessica McElligott, Christa Attkisson, Michael Betteken, David L Popham
Homologues of the Bacillus subtilis SpoVB protein are involved in cell wall metabolism.
J Bacteriol: 2009, 191(19);6012-9
[PubMed:19648239] [WorldCat.org] [DOI] (I p)

Kei Asai, Hiromu Takamatsu, Megumi Iwano, Takeko Kodama, Kazuhito Watabe, Naotake Ogasawara
The Bacillus subtilis yabQ gene is essential for formation of the spore cortex.
Microbiology (Reading): 2001, 147(Pt 4);919-927
[PubMed:11283287] [WorldCat.org] [DOI] (P p)