YloH

• Description: omega subunit of RNA polymerase
  
  

Gene name	yloH
Synonyms
Essential	no
Product	omega subunit of RNA polymerase
Function	unknown
Gene expression levels in SubtiExpress: yloH
Interactions involving this protein in SubtInteract: YloH
Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation)
MW, pI	7 kDa, 5.513
Gene length, protein length	201 bp, 67 aa
Immediate neighbours	gmk, yloI
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription

The gene

Basic information

• Locus tag: BSU15690

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1) (according to Swiss-Prot)

• Protein family: RNA polymerase subunit omega family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • closely associated to RNA polymerase (RpoA(2)-RpoB-RpoC) PubMed

• Localization:
  • closely associated with RNA polymerase involved in transcribing both mRNA and rRNA operons PubMed

Database entries

• Structure:

• UniProt: O35011

• KEGG entry: [2]

• E.C. number: 2.7.7.6

Expression and regulation

• Operon:

• Expression browser: yloH PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • present about at half the amount of core RNA polymerase PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Lakshminarayan M Iyer, L Aravind
Insights from the architecture of the bacterial transcription apparatus.
J Struct Biol: 2012, 179(3);299-319
[PubMed:22210308] [WorldCat.org] [DOI] (I p)

Original publications

Additional publications: PubMed

L Minakhin, S Bhagat, A Brunning, E A Campbell, S A Darst, R H Ebright, K Severinov
Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.
Proc Natl Acad Sci U S A: 2001, 98(3);892-7
[PubMed:11158566] [WorldCat.org] [DOI] (P p)