AdhA

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  • Description: thiol-dependent aldehyde dehydrogenase, repair of damaged thiol-containing proteins

Gene name adhA
Synonyms
Essential no
Product thiol-dependent aldehyde dehydrogenase,
reduction of aldehydes
Function response to toxic formaldehyde
MW, pI 37 kDa, 5.367
Gene length, protein length 1047 bp, 349 aa
Immediate neighbours adhR, yraA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AdhA context.gif
This image was kindly provided by SubtiList






Categories containing this gene/protein

resistance against oxidative and electrophile stress

This gene is a member of the following regulons

AdhR regulon

The gene

Basic information

  • Locus tag: BSU27010

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced in the presence of the toxic carbonyls methylglyoxal and formaldehyde (AdhR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Thi Thu Huyen Nguyen, Warawan Eiamphungporn, Ulrike Mäder, Manuel Liebeke, Michael Lalk, Michael Hecker, John D Helmann, Haike Antelmann
Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).
Mol Microbiol: 2009, 71(4);876-94
[PubMed:19170879] [WorldCat.org] [DOI] (I p)