Fur
- Description: transcription regulator of iron homoeostasis
| Gene name | fur |
| Synonyms | yqkL |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of iron homoeostasis
and transcription of ferri-siderophore uptake genes |
| Metabolic function and regulation of this protein in SubtiPathways: Metal ion homeostasis, Alternative nitrogen sources, Protein secretion | |
| MW, pI | 17 kDa, 5.374 |
| Gene length, protein length | 447 bp, 149 aa |
| Immediate neighbours | ripX, spoIIM |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
acquisition of iron, iron metabolism, transcription factors and their control
This gene is a member of the following regulons
The Fur regulon
The gene
Basic information
- Locus tag: BSU23520
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: Fur family (according to Swiss-Prot)
Genes controlled by Fur
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): contains an iron-sulfur cluster
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P54574
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: fur PubMed
- Additional information:
Biological materials
- Mutant: HB6543 (aphA3), available in the John Helmann lab; also available in the Stülke lab GP879 (fur::mls) and GP868 (fur::mls, perR::spc)
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
The Fur regulon
Other original publications
