SdpI

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  • Description: immunity protein, protection against SdpC

Gene name sdpI
Synonyms yvaZ
Essential no
Product immunity protein
Function protection against SdpC
MW, pI 23 kDa, 9.61
Gene length, protein length 621 bp, 207 aa
Immediate neighbours sdpC, sdpR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YvaZ context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

toxins, antitoxins and immunity against toxins, membrane proteins

This gene is a member of the following regulons

AbrB regulon, SdpR regulon

The gene

Basic information

  • Locus tag: BSU33780

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: in the presence of extracellular SdpC, SdpI binds and sequesters SdpR , this results in induction of the sdpR-sdpI operon PubMed
  • Localization: membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

José Eduardo González-Pastor
Cannibalism: a social behavior in sporulating Bacillus subtilis.
FEMS Microbiol Rev: 2011, 35(3);415-24
[PubMed:20955377] [WorldCat.org] [DOI] (I p)

Original Publications

Tatyana Leonidovna Povolotsky, Ekaterina Orlova, Dorjee G Tamang, Milton H Saier
Defense against cannibalism: the SdpI family of bacterial immunity/signal transduction proteins.
J Membr Biol: 2010, 235(3);145-62
[PubMed:20563570] [WorldCat.org] [DOI] (I p)

Craig D Ellermeier, Errett C Hobbs, Jose E Gonzalez-Pastor, Richard Losick
A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin.
Cell: 2006, 124(3);549-59
[PubMed:16469701] [WorldCat.org] [DOI] (P p)

José E González-Pastor, Errett C Hobbs, Richard Losick
Cannibalism by sporulating bacteria.
Science: 2003, 301(5632);510-3
[PubMed:12817086] [WorldCat.org] [DOI] (I p)