ProG

• Description: 1-pyrroline-5-carboxylate dehydrogenase
  
  

Gene name	proG
Synonyms	ykeA, yzcA
Essential	no
Product	1-pyrroline-5-carboxylate dehydrogenase
Function	biosynthesis of proline
Metabolic function and regulation of this protein in SubtiPathways: Pro, Stress
MW, pI	30 kDa, 4.914
Gene length, protein length	816 bp, 272 aa
Immediate neighbours	htrA, dppA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

The gene

Basic information

• Locus tag: BSU12910

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H (according to Swiss-Prot)

• Protein family: pyrroline-5-carboxylate reductase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: Q00777

• KEGG entry: [3]

• E.C. number: 1.5.1.2

Expression and regulation

• Operon: proG PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

B R Belitsky, J Brill, E Bremer, A L Sonenshein
Multiple genes for the last step of proline biosynthesis in Bacillus subtilis.
J Bacteriol: 2001, 183(14);4389-92
[PubMed:11418582] [WorldCat.org] [DOI] (P p)

C Mathiopoulos, J P Mueller, F J Slack, C G Murphy, S Patankar, G Bukusoglu, A L Sonenshein
A Bacillus subtilis dipeptide transport system expressed early during sporulation.
Mol Microbiol: 1991, 5(8);1903-13
[PubMed:1766370] [WorldCat.org] [DOI] (P p)