NfrA

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  • Description: Spx-dependent FMN-containing NADPH-linked nitro/flavin reductase, stress protein

Gene name nfrA
Synonyms ywcG, ipa-43d
Essential no
Product FMN-containing NADPH-linked nitro/flavin reductase
Function unknown
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 28 kDa, 5.732
Gene length, protein length 747 bp, 249 aa
Immediate neighbours ywcH, rodA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
NfrA context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

electron transport/ other, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

SigD regulon, Spo0A regulon, Spx regulon

The gene

Basic information

  • Locus tag: BSU38110

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: possesses an NADH oxidase activity that leads to high concentrations of oxygen peroxide and an NAD(+) degrading activity leading to free nicotinamide PubMed
  • Protein family: flavin oxidoreductase frp family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References