DppA

• Description: D-alanyl-aminopeptidase
  
  

Gene name	dppA
Synonyms	dciAA
Essential	no
Product	D-alanyl-aminopeptidase
Function	degradation of cell wall peptides
MW, pI	30 kDa, 5.19
Gene length, protein length	822 bp, 274 aa
Immediate neighbours	proG, dppB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of nitrogen sources other than amino acids, phosphoproteins

This gene is a member of the following regulons

AbrB regulon, CodY regulon

The gene

Basic information

• Locus tag: BSU12920

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: peptidase M55 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on ser/ thr/ tyr PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1HI9

• UniProt: P26902

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: dppA-dppB-dppC-dppD-dppE PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (2.9-fold) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • repressed during logrithmic growth (AbrB) PubMed

• Regulatory mechanism:
  • CodY: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: