CsfB

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  • Description: forespore-specific protein, inhibitor of SigG and of SigE

Gene name csfB
Synonyms yaaM
Essential no
Product inhibitor of SigG and SigE
Function control of SigG and SigE activity
MW, pI 7 kDa, 7.671
Gene length, protein length 192 bp, 64 aa
Immediate neighbours rrnA-5S, xpaC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CsfB context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU00240

Phenotypes of a mutant

premature activation of SigG PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: forespore

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: csfB
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Lamya Rhayat, Sandra Duperrier, Rut Carballido-López, Olivier Pellegrini, Patrick Stragier
Genetic dissection of an inhibitor of the sporulation sigma factor sigma(G).
J Mol Biol: 2009, 390(5);835-44
[PubMed:19497328] [WorldCat.org] [DOI] (I p)

Céline Karmazyn-Campelli, Lamya Rhayat, Rut Carballido-López, Sandra Duperrier, Niels Frandsen, Patrick Stragier
How the early sporulation sigma factor sigmaF delays the switch to late development in Bacillus subtilis.
Mol Microbiol: 2008, 67(5);1169-80
[PubMed:18208527] [WorldCat.org] [DOI] (I p)

A Decatur, R Losick
Identification of additional genes under the control of the transcription factor sigma F of Bacillus subtilis.
J Bacteriol: 1996, 178(16);5039-41
[PubMed:8759874] [WorldCat.org] [DOI] (P p)

C D Webb, A Decatur, A Teleman, R Losick
Use of green fluorescent protein for visualization of cell-specific gene expression and subcellular protein localization during sporulation in Bacillus subtilis.
J Bacteriol: 1995, 177(20);5906-11
[PubMed:7592342] [WorldCat.org] [DOI] (P p)

Vasant K Chary, Panagiotis Xenopoulos, Avigdor Eldar, Patrick J Piggot
Loss of compartmentalization of σ(E) activity need not prevent formation of spores by Bacillus subtilis.
J Bacteriol: 2010, 192(21);5616-24
[PubMed:20802044] [WorldCat.org] [DOI] (I p)

Vasant K Chary, Panagiotis Xenopoulos, Patrick J Piggot
Expression of the sigmaF-directed csfB locus prevents premature appearance of sigmaG activity during sporulation of Bacillus subtilis.
J Bacteriol: 2007, 189(23);8754-7
[PubMed:17921305] [WorldCat.org] [DOI] (I p)

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)