AdhR
| Gene name | adhR |
| Synonyms | yraB |
| Essential | no |
| Product | transcriptional activator (MerR family) |
| Function | regulation of the protective response to formaldehyde |
| MW, pI | 16 kDa, 9.637 |
| Gene length, protein length | 420 bp, 140 aa |
| Immediate neighbours | yraD, adhA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU27000
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
Categories containing this gene/protein
transcription factors and their control, resistance against oxidative and electrophile stress
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: activity probably controlled via thiol-(S)-alkylation in Cys-52 PubMed
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: spore wall (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: O06008
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Thi Thu Huyen Nguyen, Warawan Eiamphungporn, Ulrike Mäder, Manuel Liebeke, Michael Lalk, Michael Hecker, John D Helmann, Haike Antelmann
Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).
Mol Microbiol: 2009, 71(4);876-94
[PubMed:19170879]
[WorldCat.org]
[DOI]
(I p)
