HemQ

• Description: heme-binding protein, essential for heme biosynthesis
  
  

Gene name	hemQ
Synonyms	ipa-87r, ywfI
Essential	no
Product	heme-binding protein
Function	biosynthesis of heme
MW, pI	29 kDa, 4.972
Gene length, protein length	762 bp, 254 aa
Immediate neighbours	pta, ywfH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU37670

Phenotypes of a mutant

defect in heme biosynthesis

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: UPF0447 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Ser-41 PubMed

• Cofactor(s): heme

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1TOT (Geobacillus stearothermophilus)

• UniProt: P39645

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ywfI PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Tamara A Dailey, Tye O Boynton, Angela-Nadia Albetel, Svetlana Gerdes, Michael K Johnson, Harry A Dailey
Discovery and Characterization of HemQ: an essential heme biosynthetic pathway component.
J Biol Chem: 2010, 285(34);25978-86
[PubMed:20543190] [WorldCat.org] [DOI] (I p)

Boris Macek, Ivan Mijakovic, Jesper V Olsen, Florian Gnad, Chanchal Kumar, Peter R Jensen, Matthias Mann
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis.
Mol Cell Proteomics: 2007, 6(4);697-707
[PubMed:17218307] [WorldCat.org] [DOI] (P p)

E Presecan, I Moszer, L Boursier, H Cruz Ramos, V de la Fuente, M-F Hullo, C Lelong, S Schleich, A Sekowska, B H Song, G Villani, F Kunst, A Danchin, P Glaser
The Bacillus subtilis genome from gerBC (311 degrees) to licR (334 degrees).
Microbiology (Reading): 1997, 143 ( Pt 10);3313-3328
[PubMed:9353933] [WorldCat.org] [DOI] (P p)