DapG

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• Description: aspartokinase I (alpha and beta subunits) <br/><br/>

Gene name	dapG
Synonyms	lssD
Essential	no
Product	aspartokinase I (alpha and beta subunits)
Function	biosynthesis of lysine and peptidoglycan
Metabolic function and regulation of this protein in SubtiPathways: <br/>Lys, Thr
MW, pI	42 kDa, 5.709
Gene length, protein length	1212 bp, 404 aa
Immediate neighbours	asd, dapA
Get the DNA and protein sequences <br/> (Barbe et al., 2009)
Genetic context <br/> <div align="right"> <small>This image was kindly provided by SubtiList</small></div>

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The gene

Basic information

• Locus tag: BSU16760

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + L-aspartate = ADP + 4-phospho-L-aspartate (according to Swiss-Prot)

• Protein family: aspartokinase family (according to Swiss-Prot)

• Paralogous protein(s): LysC

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: inhibited by diaminopimelic acid PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: Q04795

• KEGG entry: [3]

• E.C. number: 2.7.2.4

Expression and regulation

• Operon:
  • spoVFA-spoVFB-asd-dapG-dapA PubMed
  • asd-dapG-dapA PubMed

• Sigma factor:
  • spoVFA: SigK PubMed
  • asd: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

<pubmed>19946135 ,, </pubmed>

Original publications

<pubmed>8345520,,15699190 8098035,2152900 , </pubmed>