YabM

• Description: may function in a previously observed alternate pathway for peptidoglycan strand synthesis
  
  

Gene name	yabM
Synonyms
Essential	no
Product	unknown
Function	alternate pathway for peptidoglycan strand synthesis
MW, pI	57 kDa, 9.623
Gene length, protein length	1596 bp, 532 aa
Immediate neighbours	spoVT, yabN
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU00570

Phenotypes of a mutant

Mutants lacking YabM exhibit sensitivity to moenomycin, an antibiotic that blocks peptidoglycan polymerization by class A penicillin-binding proteins. PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: may function in a previously observed alternate pathway for peptidoglycan strand synthesis PubMed

• Protein family: polysaccharide synthase family (according to Swiss-Prot)

• Paralogous protein(s): SpoVB, YkvU, YtgP

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P37555

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yabM-yabN-yabO-yabP-yabQ-divIC-yabR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Allison Fay, Jonathan Dworkin
Bacillus subtilis homologs of MviN (MurJ), the putative Escherichia coli lipid II flippase, are not essential for growth.
J Bacteriol: 2009, 191(19);6020-8
[PubMed:19666716] [WorldCat.org] [DOI] (I p)

Pradeep Vasudevan, Jessica McElligott, Christa Attkisson, Michael Betteken, David L Popham
Homologues of the Bacillus subtilis SpoVB protein are involved in cell wall metabolism.
J Bacteriol: 2009, 191(19);6012-9
[PubMed:19648239] [WorldCat.org] [DOI] (I p)

Kei Asai, Hiromu Takamatsu, Megumi Iwano, Takeko Kodama, Kazuhito Watabe, Naotake Ogasawara
The Bacillus subtilis yabQ gene is essential for formation of the spore cortex.
Microbiology (Reading): 2001, 147(Pt 4);919-927
[PubMed:11283287] [WorldCat.org] [DOI] (P p)