GltR

• Description: transcriptional regulator (LysR family)
  
  

Gene name	gltR
Synonyms	yrdL
Essential	no
Product	transcriptional regulator (LysR family)
Function	unknown
MW, pI	32 kDa, 6.653
Gene length, protein length	888 bp, 296 aa
Immediate neighbours	yrdN, yrdK
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU26670

Phenotypes of a mutant

The function of this protein is unknown. However, certain mutant forms are able to activate expression of the gltA-gltB operon (and thus to replace the cognate activator protein GltC)

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: LysR family of transcription factors

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P94501

• KEGG entry: [3]

• E.C. number:

Additional information

The function of this protein is unknown. However, certain mutant forms are able to activate expression of the gltA-gltB operon (and thus to replace the cognate activator protein GltC)

Expression and regulation

• Operon: gltR (according to DBTBS)

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • GltR: negative autoregulation PubMed

• Additional information:

Biological materials

• Mutant: GP345 (erm), available in the Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Linc Sonenshein, Tufts University, Boston, MA, USA Homepage

References

B R Belitsky, A L Sonenshein
Altered transcription activation specificity of a mutant form of Bacillus subtilis GltR, a LysR family member.
J Bacteriol: 1997, 179(4);1035-43
[PubMed:9023181] [WorldCat.org] [DOI] (P p)