NucB

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  • Description: sporulation-specific extracellular nuclease

Gene name nucB
Synonyms
Essential no
Product sporulation-specific extracellular nuclease
Function DNA degradation after mother cell lysis
MW, pI 14 kDa, 5.173
Gene length, protein length 408 bp, 136 aa
Immediate neighbours yqeB, spoIVCB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
NucB context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU25750

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: expressed during sporulation (SigE) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Shigeo Hosoya, Zuolei Lu, Yousuke Ozaki, Michio Takeuchi, Tsutomu Sato
Cytological analysis of the mother cell death process during sporulation in Bacillus subtilis.
J Bacteriol: 2007, 189(6);2561-5
[PubMed:17209033] [WorldCat.org] [DOI] (P p)

D van Sinderen, R Kiewiet, G Venema
Differential expression of two closely related deoxyribonuclease genes, nucA and nucB, in Bacillus subtilis.
Mol Microbiol: 1995, 15(2);213-23
[PubMed:7746143] [WorldCat.org] [DOI] (P p)