DgkA

• Description: undecaprenol kinase
  
  

Gene name	dgkA
Synonyms	yqxF
Essential	no
Product	undecaprenol kinase
Function	biosynthesis of peptidoglycan
MW, pI	12 kDa, 7.128
Gene length, protein length	342 bp, 114 aa
Immediate neighbours	cdd, yqfG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU25310

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bacterial diacylglycerol kinase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P19638

• KEGG entry: [2]

• E.C. number: 2.7.1.107

Additional information

The gene is annotated in KEGG/MetaCyc/Swiss-Prot as diacylglycerol kinase EC 2.7.1.107. However, in the recently published paper (July 2007) by Jerga et al  PubMed, the authors confirmed that dgkA is not a diacylglycerol kinase (DagK) but rather an undecaprenol kinase. This annotation was removed from Swiss-Prot as of November 2009.  PubMed

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Agoston Jerga, Ying-Jie Lu, Gustavo E Schujman, Diego de Mendoza, Charles O Rock
Identification of a soluble diacylglycerol kinase required for lipoteichoic acid production in Bacillus subtilis.
J Biol Chem: 2007, 282(30);21738-45
[PubMed:17535816] [WorldCat.org] [DOI] (P p)

Samuel Amiteye, Kazuo Kobayashi, Daisuke Imamura, Shigeo Hosoya, Naotake Ogasawara, Tsutomu Sato
Bacillus subtilis diacylglycerol kinase (DgkA) enhances efficient sporulation.
J Bacteriol: 2003, 185(17);5306-9
[PubMed:12923107] [WorldCat.org] [DOI] (P p)