KduD

• Description: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
  
  

Gene name	kduD
Synonyms
Essential	no
Product
Function	utilization of galacturonic acid
MW, pI	27 kDa, 6.498
Gene length, protein length	762 bp, 254 aa
Immediate neighbours	kduI, ypvA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU22140

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 2-deoxy-D-gluconate + NAD⁺ = 3-dehydro-2-deoxy-D-gluconate + NADH (according to Swiss-Prot)

• Protein family: phosphopentomutase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P50842

• KEGG entry: [2]

• E.C. number: 1.1.1.125

Expression and regulation

• Operon: kduI-kduD PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by galacturonate (KdgR) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • KdgR: transcription repression PubMed
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jer-Sheng Lin, Gwo-Chyuan Shaw
Regulation of the kduID operon of Bacillus subtilis by the KdgR repressor and the ccpA gene: identification of two KdgR-binding sites within the kdgR-kduI intergenic region.
Microbiology (Reading): 2007, 153(Pt 3);701-710
[PubMed:17322190] [WorldCat.org] [DOI] (P p)