Difference between revisions of "UreC"

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* '''Regulation:''' induced by nitrogen limitation ([[GlnR]], [[TnrA]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9287005 PubMed], repressed by [[CodY]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12618455 PubMed]
 
* '''Regulation:''' induced by nitrogen limitation ([[GlnR]], [[TnrA]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9287005 PubMed], repressed by [[CodY]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12618455 PubMed]
 +
** induced in the presence of purine nucleotides (inducer: allantoin) ([[PucR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12374841 PubMed]
 
** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9287005 PubMed]
 
** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9287005 PubMed]
  
 
* '''Regulatory mechanism:''' [[GlnR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/9287005 PubMed], [[TnrA]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/9287005 PubMed], [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12618455 PubMed]   
 
* '''Regulatory mechanism:''' [[GlnR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/9287005 PubMed], [[TnrA]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/9287005 PubMed], [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12618455 PubMed]   
 +
** [PucR]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/12374841 PubMed]
 
** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/9287005 PubMed]
 
** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/9287005 PubMed]
  

Revision as of 17:05, 11 June 2009

  • Description: urease (alpha subunit)

Gene name ureC
Synonyms
Essential no
Product urease (alpha subunit)
Function utilization of urea as alternative nitrogen source
MW, pI 61 kDa, 5.091
Gene length, protein length 1707 bp, 569 aa
Immediate neighbours ywnA, ureB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
UreC context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU36640

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Urea + H2O = CO2 + 2 NH3 (according to Swiss-Prot)
  • Protein family: urease family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation: induced by nitrogen limitation (GlnR, TnrA) PubMed, repressed by CodY PubMed
    • induced in the presence of purine nucleotides (inducer: allantoin) (PucR) PubMed
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed