Difference between revisions of "NadC"

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* '''Regulation:'''  
 
* '''Regulation:'''  
 +
** repressed in the presence of nicotinic acid ([[NadR]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/16199587 PubMed]
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[NadR]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/16199587 PubMed]
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  

Revision as of 16:55, 11 June 2009

  • Description: nicotinate-nucleotide diphosphorylase (carboxylating)

Gene name nadC
Synonyms yrxB
Essential no
Product nicotinate-nucleotide diphosphorylase (carboxylating)
Function NAD biosynthesis
MW, pI 31 kDa, 5.18
Gene length, protein length 867 bp, 289 aa
Immediate neighbours nadA, nadB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
NadC context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU27860

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family: nadC/modD family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • repressed in the presence of nicotinic acid (NadR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed