gtcA

168

flippase, transports the glucose-phosphate moiety of C₅₅-P-Glc across the membrane, teichoic acid glycosylation protein

Locus: BSU_38210

Molecular weight: 14.21 kDa

Isoelectric point: 8.5

Protein length: 127 aa

Gene length: 384 bp

Function: glycosylation of teichoic acids

Product: flippase for teichoic acid glycosylation

Essential: no

Synonyms: gtcA, ywcD, ipa-34d, gtaC

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG2246 (Galperin et al., 2021)

Gene

Coordinates: 3,921,891 → 3,922,274

Phenotypes of a mutant

• inactivation suppresses the essentiality of mbl PubMed

The protein

Protein family

• GtrA family (with YngA, according to UniProt)

Structure

• P39602 (AlphaFold)

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: ywcC-gtcA-galK-galT

  Description: PubMed

  Regulation

  • repressed by glucose (CcpA) PubMed

Biological materials

Mutant

• MGNA-B231 (ywcD::erm), available at the NBRP B. subtilis, Japan
• BKE38210 (ΔgtcA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAATTATTTCTCTATACT,  downstream forward: _UP4_TGAGAGGACTGCAGCATATG
• BKK38210 (ΔgtcA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAATTATTTCTCTATACT,  downstream forward: _UP4_TGAGAGGACTGCAGCATATG

References

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