MciZ

• Description: FtsZ inhibition peptide
  
  

Gene name	mciZ
Synonyms
Essential	no
Product	FtsZ inhibition peptide
Function	inhibits GTPase activity of FtsZ and Z ring formation during sporulation
Gene expression levels in SubtiExpress: mciZ
Interactions involving this protein in SubtInteract: MciZ
MW, pI	4.8 kDa, y.yy
Gene length, protein length	120 bp, 40 aa
Immediate neighbours	nudF, yqkF
Gene sequence (+200bp)	Protein sequence
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

cell division, short peptides

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: no entry

• SubtiList entry: no entry

Additional information

This gene was only recently identified. PubMed

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: inhibits GTPase activity of FtsZ and Z ring formation during sporulation PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • MciZ-FtsZ PubMed, K_D: 150 nM PubMed

• Localization:

Database entries

• Structure:
  • 2MRW PubMed
  • 4U39 (FtsZ-MciZ complex) PubMed

• Swiss prot entry:

• KEGG entry: no entry

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: mciZ PubMed

• Sigma factor: SigE PubMed

• Regulation:
  • expressed early during sporulation in the mother cell (SigE) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

David W Adams, Jeff Errington
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
Nat Rev Microbiol: 2009, 7(9);642-53
[PubMed:19680248] [WorldCat.org] [DOI] (I p)

Original Publications

Alexandre W Bisson-Filho, Karen F Discola, Patrícia Castellen, Valdir Blasios, Alexandre Martins, Maurício L Sforça, Wanius Garcia, Ana Carolina M Zeri, Harold P Erickson, Andréa Dessen, Frederico J Gueiros-Filho
FtsZ filament capping by MciZ, a developmental regulator of bacterial division.
Proc Natl Acad Sci U S A: 2015, 112(17);E2130-8
[PubMed:25848052] [WorldCat.org] [DOI] (I p)

Aaron A Handler, Joo Eun Lim, Richard Losick
Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis.
Mol Microbiol: 2008, 68(3);588-99
[PubMed:18284588] [WorldCat.org] [DOI] (I p)