YciC

• Description: putative metallochaperone
  
  

Gene name	yciC
Synonyms
Essential	no
Product	putative metallochaperone
Function	zinc uptake
Gene expression levels in SubtiExpress: yciC
Metabolic function and regulation of this protein in SubtiPathways: yciC
MW, pI	45 kDa, 4.399
Gene length, protein length	1191 bp, 397 aa
Immediate neighbours	yczL, yckA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), membrane proteins, phosphoproteins

This gene is a member of the following regulons

Zur regulon

The gene

Basic information

• Locus tag: BSU03360

Database entries

• BsubCyc: BSU03360

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: cobW C-terminal domain (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-58 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: membrane associated PubMed

Database entries

• BsubCyc: BSU03360

• Structure:

• UniProt: P94400

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • yciA-yciB-yciC PubMed
  • yciC PubMed

• Expression browser: yciC PubMed

• Sigma factor:
  • yciA:SigA PubMed
  • yciC:SigA PubMed

• Regulation:
  • yciA: induced by zinc starvation (Zur) PubMed
  • yciC: induced by zinc starvation (Zur) PubMed

• Regulatory mechanism:
  • yciA: Zur: transcription repression in the presence of zinc PubMed
  • yciC: Zur: transcription repression in the presence of zinc PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 448 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage