ClpY

• Description: two-component ATP-dependent protease, ATPase subunit
  
  

Gene name	clpY
Synonyms	hslU, codX
Essential	no
Product	two-component ATP-dependent protease, ATPase subunit
Function	protein degradation
Gene expression levels in SubtiExpress: clpY
Interactions involving this protein in SubtInteract: ClpY
MW, pI	52 kDa, 5.31
Gene length, protein length	1401 bp, 467 aa
Immediate neighbours	clpQ, codY
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

proteolysis

This gene is a member of the following regulons

CodY regulon

The gene

Basic information

• Locus tag: BSU16160

Database entries

• BsubCyc: BSU16160

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: HslU subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • ClpQ-ClpY PubMed

• Localization:

Database entries

• BsubCyc: BSU16160

• Structure:

• UniProt: P39778

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: codV-clpQ-clpY-codY PubMed

• Expression browser: clpY PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed

• Regulatory mechanism:
  • CodY: transcription repression PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 854 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 1936 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Additional reviews: PubMed