InfC

• Description: translation initiation factor IF-3
  
  

Gene name	infC
Synonyms
Essential	yes PubMed
Product	initiation factor IF-3
Function	translation
Gene expression levels in SubtiExpress: infC
MW, pI	19 kDa, 10.342
Gene length, protein length	519 bp, 173 aa
Immediate neighbours	rpmI, yscB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

translation, essential genes

This gene is a member of the following regulons

RplT regulon, stringent response

The gene

Basic information

• Locus tag: BSU28870

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU28870

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: IF-3 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU28870

• Structure: 1TIF (N-terminal domain, Geobacillus stearothermophilus), 1TIG (C-terminal domain, Geobacillus stearothermophilus)

• UniProt: P55872

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: infC-rpmI-rplT-ysdA PubMed

• Expression browser: infC PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • RelA dependent downregulation (Class I) during stringent response PubMed

• Regulatory mechanism:
  • binding of RplT to a RNA switch in the infC leader region causes transcription termination PubMed

• Additional information:
  • expression of IF3 is uncoupled from that of L35 and L20 by RNase Y-dependent processing PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: