Difference between revisions of "RsbR"

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(Original Articles)
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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU04670&redirect=T BSU04670]
  
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/rsbRSTUVW-sigB-rsbX.html]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/rsbRSTUVW-sigB-rsbX.html]
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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU04670&redirect=T BSU04670]
  
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2BNL 2BNL] (N-terminal domain),  [http://www.rcsb.org/pdb/explore.do?structureId=3VY9 3VY9] (complete stressosome)
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2BNL 2BNL] (N-terminal domain),  [http://www.rcsb.org/pdb/explore.do?structureId=3VY9 3VY9] (complete stressosome)

Revision as of 13:02, 2 April 2014

  • Description: activator of RsbT kinase activity, stressosome sensor protein
Gene name rsbR
Synonyms ycxR, rsbRA
Essential no
Product activator of RsbT kinase activity, stressosome sensor protein
Function control of SigB activity
Gene expression levels in SubtiExpress: rsbR
Interactions involving this protein in SubtInteract: RbsR
Metabolic function and regulation of this protein in SubtiPathways:
rsbR
MW, pI 30 kDa, 4.731
Gene length, protein length 822 bp, 274 aa
Immediate neighbours ndoA, rsbS
Sequences Protein DNA DNA_with_flanks
Genetic context
RsbR context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RsbR expression.png















Categories containing this gene/protein

sigma factors and their control, phosphoproteins, most abundant proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU04670

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • positive regulator of YtvA-dependent light activation of the SigB stress response PubMed
    • phosphorylated RsbR activates the kinase activity of RsbT PubMed
  • Protein family:

Extended information on the protein

  • Kinetic information:
  • Domains:
    • RsbRA is composed of an N-terminal nonheme globin domain and a highly conserved C-terminal STAS (Sulphate Transporter and AntiSigma factor antagonist) domain. The C-terminal STAS domain is the target of the serine/threonine-specific kinase RsbT (see below).
  • Modification: phosphorylation on Thr-171 and Thr-205 by RsbT PubMed
  • Effectors of protein activity:

Database entries

  • Structure: 2BNL (N-terminal domain), 3VY9 (complete stressosome)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: constitutively expressed PubMed
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews


Original Articles