Difference between revisions of "MtrB"
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= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| − | + | = The [[TRAP regulon]] = | |
=The gene= | =The gene= | ||
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* '''Paralogous protein(s):''' | * '''Paralogous protein(s):''' | ||
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=== Extended information on the protein === | === Extended information on the protein === | ||
Revision as of 10:39, 2 April 2014
- Description: tryptophan operon RNA-binding attenuation protein (TRAP), controls the RNA switch in front of genes involved in biosynthesis and acquisition of tryptophan
| Gene name | mtrB |
| Synonyms | |
| Essential | no |
| Product | tryptophan operon RNA-binding attenuation protein (TRAP) |
| Function | regulation of tryptophan biosynthesis (and translation) attenuation in the trp operon; repression of the folate operon |
| Gene expression levels in SubtiExpress: mtrB | |
| Interactions involving this protein in SubtInteract: TRAP | |
| Metabolic function and regulation of this protein in SubtiPathways: mtrB | |
| MW, pI | 8 kDa, 7.333 |
| Gene length, protein length | 225 bp, 75 aa |
| Immediate neighbours | hepS, folE |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, transcription factors and their control, RNA binding regulators
This gene is a member of the following regulons
The TRAP regulon
The gene
Basic information
- Locus tag: BSU22770
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
- mutations in mtrB, sigB, rpoB, and rpoC allow B. subtilis to grow with 4-fluorotryptophan rather than with tryptophan as a canonical amino acid of the genetic code PubMed
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: prpD family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- binding of tryptophan results RNA binding and thus in transcription termination
Database entries
- UniProt: P19466
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Paul Babitzke, Carol S Baker, Tony Romeo
Regulation of translation initiation by RNA binding proteins.
Annu Rev Microbiol: 2009, 63;27-44
[PubMed:19385727]
[WorldCat.org]
[DOI]
(I p)
Paul Gollnick, Paul Babitzke, Alfred Antson, Charles Yanofsky
Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis.
Annu Rev Genet: 2005, 39;47-68
[PubMed:16285852]
[WorldCat.org]
[DOI]
(P p)
Paul Babitzke
Regulation of transcription attenuation and translation initiation by allosteric control of an RNA-binding protein: the Bacillus subtilis TRAP protein.
Curr Opin Microbiol: 2004, 7(2);132-9
[PubMed:15063849]
[WorldCat.org]
[DOI]
(P p)
Original Publications
